Human Health TDC

Human Health TDC

AMAP Thematic Data Centres compile data from relevant monitoring and research activities and make them available under strict conditions that protect the rights of data originators. AMAP TDCs are located at established centres with appropriate expertise and facilities for conducting the types of international data handling required. For more information, please visit the main AMAP website.

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1. Effects of prenatal exposure to OCs and mercury on the immune system of Inuit infants (year 3)

This study investigates possible detrimental effects on the immune system of Inuit infants which may be induced by prenatal and postnatal (breast feeding) exposure to persistent environmental contaminants such as organochlorine compounds. These substances accumulate in the body of Inuit women in part due to their consumption of sea mammal fat and can be transferred to the foetus during pregnacy and to the infant during breast feeding. Immune system function will be evaluated using several parameters: 1) the level of antibody produced by the infant following Haemophilus influenza immunization; 2) the level of proteins which protect the infant against bacterial infections (complement system) before its immune system is fully developed; and 3) the level of chemical messengers (cytokines) which enable the various cells of the immune system to communicate with each other, thereby maintaining its proper function and assuring the protection of the infant against bacteria, parasitic and viral infections.

Organochlorines Inuit infants mercury vitamin A prenatal exposure assessment Human health