FT-IR spectrometers are capable to quantifiy the total column amounts of many important trace gases in the troposphere and stratosphere. At present the following species are retrieved from the Kiruna data: O3 (ozone), ClONO2, HNO3, HCl, CFC-11, CFC-12, CFC-22, NO2, N2O, NO, HF, C2H2, C2H4, C2H6, CH4, CO, COF2, H2O, HCN, HO2NO2, NH3, N2, and OCS Selected research topics and activities: chemical ozone depletion by observation of key species (O3, ClONO2, HNO3, HCl, ..) details of the ozone formation process by isotopic studies in ozone profile retrieval to detect dynamical changes transport studies of chemical tracers and tropospheric pollutants satellite validation