Follow-up of preschool aged children exposed to PCBs and mercury through fish and marine mammal consumption.

Updated 2000-06-20

The purpose of this research is to examine the long term consequences of prenatal exposure to PCBs and MeHg. This project is designed to study domains of effects overlooked in most of the previous studies. Of particular interest is the impact of exposure on neurophysiological and neurological endpoints that could be related to learning difficulties and disabilities. This study will support the health risk assessment process by providing dose-effect analysis for the neurophysiological and neurological domains of effects of preschool age children from Nunavik (Canada). The total sample will comprise 100 Nunavik Inuit children aged 5-6years. The following exclusion criteria will be applied: Apgar below 5 at 5 minutes of life, evidence of birth trauma, less than 37 weeks of gestation and less than 2500 grams at birth, congenital or chromosomal anomalies, epilepsy, significant disease history, major neurological impairment, fetal alcohol syndrome, presence of facial dysmorphologies associated with fetal alcohol effects.

This is a National Implementation Plan (NIP) project
Comments and additional information:

This prospective study is made possible because of the existence of the Nunavik Cord Blood Surveillance Program funded since 1993 by Indian and Northern Affairs Canada, Health Canada, and part of the earliest phase of the AMAP program.

Time frame

Project time span
1999 - 2000
Data collection
1999 - 2001
Data processing
2001 - 2002
Data reporting
not specified

Contact information

Contact person
Gina Muckle
Public Health Research Unit CHUL Medical Research Center 2400 D'Estimauville, Beauport (Québec) Canada, K1E 7G9
+1 418 666 7000 ext. 360
+1 418 666 2776
Other project contacts
Éric Dewailly and Pierre Ayotte Public Health Research Unit CHUL Medical Research Center 2400 D'Estimauville, Beauport (Québec), Canada, K1E 7G9

Parameters and Media

Parameter groups measured/observed/modelled
Heavy metals
Persistent organic pollutants (POPs)
Media sampled/studied/modelled
Human media


Regions studied
Persistent organic pollutants (POPs)
Persistent organic pollutants (POPs)
Other areas
Northern Québec, Nunavik

Data availability

Are data archived or planned to be archived at an AMAP Thematic Data Centre?
If no (or only part of data are reported to a TDC), where and how are (other) data stored?
Centre de Toxicologie du Québec
Samples/specimens archived in specimen banks?

Methods & Procedures

Not specified

Additional Information

Is this a bi- AND multi-lateral project (i.e. a project involving cooperation between different countries)?
Other institutes involved in the project

School of Psychology, Laval University, Quebec City Cognitive Neuroscience Laboratory, University of Quebec at Montreal, Montreal Department of Ophthalmology, Sainte-Justine Hospital, Montreal Department of Pediatrics, University of Montreal, Montreal

Is this project reporting to other organizations/programmes?

- Arctic Environmental Strategy (AES), Northern Contaminants Program, Indian and Northern Affairs Canada - MARH of DIMES Birth Defect Foundation - Fonds de Recherche en Santé du Québec - Toxic Sunstances Research Initiatives, Health Canada

Other related projects

Monitoring programs of human exposure done during first phase of the AMAP program

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