-Development of methods to enhance the rate of toxin depuration ( detoxification), especially in shellfish species of high economic value and prolonged retention e.g., King Scallops -Understanding the reaction products and metabolic transformations of toxins in shellfish tissues. -Determine the relationship between algal population dynamics ( including free cell and encysted stages ) to seasonal and spatial patterns of toxicity in shellfish populations. -Assess the effects of harmful algae on the various stages in the life history of shellfish ( Larvae, Spat, Adults ). -Investigate sampling frequencies and protocols ( live shellfish sampling ).