AMAP Project Directory

Monitoring of cesium-137 and strontium-90 in consumption milk is a sub-programme of a national monitoring program regarding environmental radiation in Sweden. The sub-programme has been ongoing since 1955. In the event of increased deposition of radionuclides, e.g. after a nuclear accident, transfer to cow milk is a quick process. The concentration in milk is therefore a good indicator of any changes of the levels of radionuclides in the area. Monitoring is performed at 5 dairies: Umeå, Sundsvall, Kallhäll, Jönköping and Malmö, where milk is sampled 4 times per year.

Monitor the levels of radionuclides (137Cs and 210Po) in selected fish and seafood species in the Norwegian and Barents Sea.

The general objective of the human health sub-programme is to protect and promote the health of Arctic peoples, especially children, with respect to exposure environmental contaminants.

Follow-up of mother-child cohort 515 childer and delivering women. Started 2006, will be followed due to AMAP protocol for 12 years

Elevated levels of 137Cs caused by previous atmospheric nuclear weapons tests fallout and the Chernobyl accident have been observed in Finnmark, Northern Norway. Due to the large consumption of potentially contaminated reindeer meat, whole body measurements of 137Cs levels in reindeer herders have been performed since 1965.

In Greenland lead contamination of the edible parts of seabirds, particularly eiders, is high because the birds have been killed with lead shot. Therefore bird-eaters are exposed to a high lead intake, probably often exceeding safe limits. In this study we will compare the lead level in human blood in a group of people from Nuuk, Greenland eating many birds with the level in a group eating few. This will enable us to assess if the high lead exposure is reflected in people and constitutes a health risk. The project is conducted in cooperation with The Medical Clinic in Nuuk and The Center for Arctic Environmental Medicine, Aarhus University.

In Greenland the human intake of mercury and cadmium from local diet is high. In an autopsy study, mercury and cadmium concentrations in humans has been analyzed. This study will make it possible to assess to what extent the high intake of mercury and cadmium is reflected in human tissue.

Persistent organic pollution is a global problem. This fact is especially apparent in the Arctic where pesticides currently used in distant environments accumulate, in some cases to higher levels than those observed in the source region. This pollution threatens the well-being of the aboriginal inhabitants of these regions. Most of the traditionally harvested animals in the Arctic are long-lived and from the higher trophic levels of the food chain, thereby providing an opportunity for considerable bioaccumulation and biomagnification of persistent contaminants. This has prompted a growing concern by the Alaska Inupiat that pollutants in the environment might be contributing to their unique morbidity and mortality rates, especially of their children. Our studies are currently focused on two specific organic pollutants found in the Arctic environment; 1}hexachlorobenzene (HCB), a byproduct during manufacture of several different chlorinated compounds and consistently detected in the Arctic and, 2} dichlorodiphenyl dichloroethylene (p,p’-DDE), a chlorinated environmental breakdown product measured in the Arctic population at significantly higher concentrations than the parent pesticide, DDT. We hypothesize that mammalian embryonic cell exposure to these chemicals, individually or as mixtures at environmentally relevant concentrations and ratios, will alter the cell cycle and/or cause death by apoptosis, rather than by necrosis. We also predict synergistic cytotoxicity of the chemical mixture because of an accumulation of deleterious effects at different cellular target sites by each chemical. We further hypothesize that while some chemicals target non-genetic cellular components (such as a cell membrane or cytosolic component), other chemical effects will occur primarily at the genetic level, directly or indirectly. Our experiments have been designed as a set of sensitive cellular and molecular assays to compare levels and types of cytotoxic and genotoxic activity of the above chemicals (individual and mixture), at environmentally relevant concentrations, upon embryonic cells in culture. Our experimental evidence thus far is that these chemicals, separately or as a mixture at concentrations and molar ratios relevant to that measured in the Arctic environment, do have cytotoxic and/or genotoxic effects that could result in profound consequences to exposed tissues of a developing embryo or fetus. We have further experimental evidence that exposure to both chemicals at environmentally relevant concentrations is more toxic to the cell than the sum of effects by exposure to the individual chemicals. Experimental results indicate this is due to different cellular target sites for each chemical (Appendix A: Preliminary Results).

Besides some beneficial effects of UV exposure, i.e. skin tanning and vitamin D production, UV ex-posure can have deleterious effects on human health. Deleterious effects are a.o. skin cancer, skin aging, wrinkling, cataract, snow blindness, and effects on the immune system. The objectives of this project are especially aimed at the detection of UV effects on the human immune system and as a consequence of the UV induced immunomodulation effects on the resistance to infections and tumors. Research activities Research activities are focussed at laboratory animal studies, studies with human volunteers, epidemiology and mathematical modelling.

Brief: Assessment of the significance of aquatic food chains as a pathways of exposure of indigenous peoples to PTS, assessment of the relative importance of local and distant sources, and the role of atmospheric and riverine transport of PTS in Northern Russia. Project rationale and objectives: (1) To assess levels of Persistent Toxic Substances (PTS) in the environment in selected areas of the Russian North, their biomagnification in aquatic and terrestrial food chains, and contamination of traditional (country) foods that are important components of the diet of indigenous peoples. (2) To assess exposure of indigenous peoples in the Russian North to PTS, and the human health impacts of pollution from local and remote sources, as a basis for actions to reduce the risks associated with these exposures. (3) To inform indigenous peoples about contamination by PTS of their environment and traditional food sources, and empower them to take appropriate remedial actions to reduce health risks. (4) To enhance the position of the Russian Federation in international negotiations to reduce the use of PTS, and to empower the Russian Association of Indigenous Peoples of the North (RAIPON) to participate actively and fully in these negotiations. Project activities to achieve outcomes: (1) Inventory of local pollution sources in the vicinities of selected indigenous communities. (2) Survey of levels and fluxes of PTS in riverine and coastal marine environment important for indigenous peoples living in these environments and using them for their subsistence; and assessment of fluxes of PTS to these environments via selected rivers and the atmosphere. (3) Dietary surveys of selected indigenous communities. (4) Study of biomagnification, based on measurements of selected PTS in representative species in food chains important for the traditional diet of indigenous populations. (5) Survey and comparative assessment of pollution levels of the indigenous and general population in selected areas. (6) Dissemination of results to all relevant stakeholders.

According to the national residue control programme heavy metals (lead, cadmium, mercury) and organochlorine compounds (HCH, HCB, DDT, PCB, etc) are analyzed from the samples. Investigations are done according to the Council Directive 96/23/EC.

The objective of this project is to obtain a comprehensive and verifiable information on contaminant exposure of indigenous populations of the Russian Barents Region through aquatic food. Subgoals: To evaluate the contaminant uptakes for blood samples that have been collected by health workers from local indigenous populations, focusing on cord blood levels. To connect and integrate the project and protocols with the ongoing cord blood study of indigenous peoples of Alaska and Eastern Russia, lead by dr. Jim Berner and others in the region.

Risk determination for traditional food should consider the potential risks from exposure to contaminants and the sociocultural, nutritional, economic and spiritual benefits associated with traditional food. Factors which influence Inuit food choices should be further analyzed to add precision to the evaluation of risks and benefits of traditional food consumption. The data of the Nutrition Santé Québec Survey are a potential source for this type of analysis since data are available and are representative of the entire region of Nunavik. The proposed work consists of more detailed analysis of the existing data on food intake among the Inuit of Nunavik collected in 1992 during the Santé Québec Health Survey and to extend our analyses to contaminant intakes. Intakes (mean and median) of traditional and market foods, nutrients and contaminants will be calculated according to the makeup/structure of households, the level of education, the level of household income and coastal place of residence. Intakes will also calculated according to the social assistance status of Inuit. Among Inuit depending on social assistance, comparisons of food, nutrient and contaminant intakes according to the time of the month in which the survey took place will be examined. Statistical comparisons of food intakes will also be done between Inuit who stated having lacked food in the month prior to the survey and those who did not. Nutrient intakes will be compared with daily recommended nutrient intakes (RNI) based on nutritional recommendations issued by Health Canada. More detailed and reliable information regarding sociodemographic factors affecting food intake, nutritional status and contaminant exposure among Inuit will help to orient public health authorities in the promotion of health through traditional food consumption.

Among all contaminants present in different aquatic ecosystems in Canada, methylmercury (MeHg) is a major source of concern for public health. Currently, it is difficult to reliably determine the threshold of MeHg concentration at which functional changes occur. On the other hand, it is well known that chronic MeHg exposure is very harmful for the nervous system. Oxidative reactions appear to be of central importance to mercury toxicity. Therefore, it is important and urgent to determine with precision the minimal dose at which oxidative stress and neurotoxic effects can be identified since some studies suggest that MeHg toxicity can be detected at level far below the minimal exposure level proposed by the World Health Organization. The main goal of this project is to investigate the effects of mercury on sensorimotor functions in the population of Salluit. We will examine the relationship between the level of MeHg and sensorimotor performance. Afterwards, specific recommendations based on quantitative evidence will be made to the concerned populations so as to diminish long-term risk on health.

This study investigates possible detrimental effects on the immune system of Inuit infants which may be induced by prenatal and postnatal (breast feeding) exposure to persistent environmental contaminants such as organochlorine compounds. These substances accumulate in the body of Inuit women in part due to their consumption of sea mammal fat and can be transferred to the foetus during pregnacy and to the infant during breast feeding. Immune system function will be evaluated using several parameters: 1) the level of antibody produced by the infant following Haemophilus influenza immunization; 2) the level of proteins which protect the infant against bacterial infections (complement system) before its immune system is fully developed; and 3) the level of chemical messengers (cytokines) which enable the various cells of the immune system to communicate with each other, thereby maintaining its proper function and assuring the protection of the infant against bacteria, parasitic and viral infections.

Short Term i) to provide additional information for use in updating health advisories. Long Term i)to investigate the fate and effects of contaminant deposition and transport to the Yukon, allowing Northerners to better manage the issue of contaminants. ii)to determine levels of contaminants for use in long term trend monitoring.

1. Continue to investigate spatial and temporal patterns in mercury concentrations in fish in lakes in the Mackenzie River Basin with a focus on predatory fish in smaller lakes near Fort Simpson but also including Great Bear Lake 2. Assess temporal trends in mercury concentrations and influencing factors, e.g., climate change 3. Conduct sediment core studies as opportunities allow to characterize long-term trends in mercury deposition and productivity 4. Integrate the findings of this study with our mercury trend monitoring in Great Slave Lake and the western provinces.

The main purpose of this research is to examine the consequences of in utero exposure to PCBs on Inuit infants, from birth to 11 months of age. Of particular interest is the impact of PCBs and mercury exposure on newborn’s thyroid hormones, physical growth, physical and central nervous system maturity, on infant’s overall health, mental, psychomotor and neurobehavioral development, and on functional and neural impairment in the domains of visual and spatial information processing. The proposed project is designed to replicate and extend previous findings by studying a more highly exposed cohort of infant, and using new infant assessment paradigms that have been linked to specific brain regions and neural pathways and, therefore, have a potential to provide information regarding possible mechanisms of action. The second objective of this research is to document the exposure to heavy metals, organochlorines and polyunsaturated fatty acids of newborns from selected communities in Nunavik. This ongoing effect study provides the opportunity to perform long time trend analysis of human exposure (data available for same communities since 1993).